Sepsis & Sepsis Six
Sepsis is the presence of infection resulting in systemic inflammatory response.
Infection and systemic inflammation results in organ dysfunction.
What are the factors which may make a patient prone to develop sepsis?
Whether a patient with infection will develop sepsis depends on a number of factors. These factors include:
1. Genetic predisposition to sepsis
2. Large microbiological load
3. Virulence of offending organism
4. Delay in source control
5. Antimicrobial resistance
6. Poor immune status/nutrition, frail patients
SOFA Score interpretation
– A score of 1–4 is allocated to six organ systems (respiratory, cardiovascular, liver, renal, coagulation and neurological) to represent the degree of organ dysfunction, e.g. platelet count >150×10 9 /L scores 1 point, <25×10 9 /L scores 4 points
– Composite score out of 24
– Higher scores are associated with increased mortality
